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Like muscle and bone, ligaments are dynamic, undergoing hypertrophy with exercising and atrophy with immobilization. This paper evaluations the structure and composition of ligaments and discusses the cellular events accountable for atrophy of ligaments with immobilization. As an experimental model, one particular knee of New Zealand White rabbits was immobilized with a pin. Just after two, four, and eight weeks of immobility, the medial collateral ligaments were isolated and enzyme evaluation was performed.
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